Micro-Electrode Array Biochips


MEA biochips are “smart” Petri dishes that consist of micro-fabricated metal electrodes (planar or 3D tip-shaped) that allow the direct measurement of electrical activity from biological preparations.

MEA biochips are realised on small glass substrates using microfabrication technologies. In order to be compatible with commercially available signal amplification and data acquisition systems, our electrode arrays are mounted onto a Printed Circuit Board (PCB). A glass ring is used to create a culture chamber, which is sealed with a biocompatible glue.

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3D Tip-Shaped Electrodes


One of our unique products is the 3D tip-shaped MEA biochip that is particularly well suited for acute tissue slice preparations. The tip-shaped electrode are able to penetrate through the initial outer dead cell layer arising from the slice preparation process, thereby enabling robust signals that come from recording healthy neurons in the interior of the slice. The tip shaped electrodes also allow more efficient electrical stimulation of the cells (M. Heuschkel et al., J. Neurosci. Methods 114 (2002) 135-148).

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Manufacturing


Qwane Biosciences has access to the Centre of Micro and Nano Technology of the Swiss Federal Institute of Technology (Lausanne, Switzerland) for high quality product development and manufacturing of MEA biochips. This cleanroom facility is equipped with state-of-the-art equipment and microfabrication technologies.

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